Normally, delivery takes place between the 37th and the 42nd week of gestation. By that time, the foetus is fully formed and developed enough to be able to adapt to extra-uterine life. However, in some cases delivery may occur before the 37th week of gestation. In that case, the neonate is considered preterm, with the degree of development of their organs being dependent on the gestational age.
Maturation and functionality of the lungs is critical for survival. Based on the degree of prematurity, lungs can be partially or even completely immature, and thus unable to ensure an adequate respiratory function.
For decades, Chiesi has been committed to neonatology, working alongside the medical community to improve the level of care for preterm babies. Thanks to this important relationship, Chiesi has become a global partner for neonatologists, bringing its life-saving drugs to more than 80 countries worldwide, and working towards the sharing of best clinical practices. Chiesi is addressing two pathologies of prematurity which are as follows:
Apnoea of Prematurity
The incomplete development of the respiratory system and the areas of the brain that regulate respiration is a common issue in preterm infants, with severity increasing in babies with a low birth weight. This condition results in episodes of spontaneous apnoea, which is usually defined as a cessation of breathing lasting more than 20 seconds.
Clinically, this interruption may be accompanied by a slower heart rate and/or a reduction of the quantity of oxygen in the blood. Finally, pale or cyanotic skin tone can occur in an infant experiencing an apnoeic episode, together with a reduction in muscle tone. Lower gestational age is associated with a higher risk of apnoeic episodes, which generally begin between 2 and 3 days of life.
Mild episodes can be resolved by tactile stimulation of the neonate, while more severe episodes need pharmacological intervention with stimulant drugs, such as caffeine.
Adenosine is a neurotransmitter that modulates neuronal activity and reduces the breathing effort. Caffeine directly opposes this effect by blocking the interaction of adenosine with its cellular receptors, thus resulting in an enhanced breathing rate.
RDS (Respiratory Distress Syndrome)
Neonatal respiratory distress syndrome is a typical condition in preterm infants. Rather than identifying a single pathology, RDS is usually used to identify a complex clinical picture whose symptoms are due to an under-development of the respiratory system. Severity and incidence of this pathology are directly linked with the degree of prematurity with infants born before the 28th week of gestation being at greater risk. Respiratory failure in preterm infants with RDS is due to a shortage in the pool of pulmonary surfactant, which helps to create a biofilm covering the inner walls of the alveoli. The physiological role of surfactant is to allow the lungs to expand and avoid collapse (atelectasis) during the expiratory phases. Lack of surfactant results in difficulty in breathing, with low oxygenation, increased breathing effort and the need for respiratory support. The pool of available surfactant in a preterm infant is usually extremely limited compared to that of a term neonate and further decreases as a result of RDS. When necessary, the administration of exogenous surfactant can alleviate the symptoms of RDS by supplementing the endogenous pool of surfactant, thereby enabling the biofilm to be replenished.
“Curosurf" Intratracheal suspension is a natural surfactant. It is administered via the intra-tracheal route in intubated infants undergoing mechanical ventilation for respiratory distress syndrome (RDS).
Curosurf" is indicated in preterm infants for the treatment of respiratory distress syndrome, or for the prophylaxis in neonates at high risk of developing RDS or with evidence of surfactant deficiency. It is advisable to commence the treatment as soon as possible after diagnosing RDS.
Administration of Curosurf
“Curosurf" is administered via the endotracheal tube as a single bolus directly into the lower tracheae administered by those trained and experienced in the care and resuscitation of preterm infants.
“Peyona" is a caffeine citrate solution, indicated for the treatment of primary apnoea in preterm neonates. It can be administered either by slow intravenous infusion or orally.
Treatment with caffeine citrate should be initiated under the supervision of a physician experienced in neonatal intensive care. Treatment should be administered only in a neonatal intensive care unit in which adequate facilities are available for patient surveillance and monitoring.
The recommended dose regimen in previously untreated infants is a loading dose administered by slow intravenous infusion, followed by a maintenance dose that may be administered either intravenously or by oral administration through a nasogastric tube.